Скачать или смотреть Immunology: T Cell Introduction | T lymphocytes | Lecture-37

TOPIC: Immunology: T Cell Introduction | T lymphocytes | Lecture-37
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Organisms are exposed to a remarkably diverse universe of pathogens and generate a remarkably diverse set of strategies to engage them. Each one of the several million T and B cells circulating in the body expresses a novel and unique antigen receptor.
T cells generate these receptors via DNA rearrangements as they mature in the thymus, an organ in our chest cavity that is both required for and dedicated to the development of T lymphocytes from precursors that arrive from the bone marrow.
Cells entering the thymus are not yet committed to becoming a lymphocyte and express no antigen-specific receptors. However, cells leaving the thymus are functional, mature T cells expressing unique and specific T-cell receptors (TCRs) that are both tolerant to self and restricted to self-MHC.
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