Endometriosis is a hormone-sensitive condition, and much of what we understand about its progression points back to estrogen dominance, especially when estrogen isn’t balanced by progesterone.
In this video, Dr. Joyce Knieff, a naturopathic doctor in Minnesota, explains how a hormone-balancing approach can support endometriosis from a functional perspective. She walks through why conventional therapies like oral contraceptives can be effective, and then breaks down what natural strategies aim to do differently.
One key focus is estrogen metabolism. Estrogen can be thought of as building up in the body like water in a bucket. Support can happen in a few ways: helping the body detox estrogen more efficiently, reducing excess estrogen production, or improving progesterone balance so estrogen isn’t unopposed.
From a detoxification standpoint, Dr. Joyce explains how Phase 2 liver pathways, especially glucuronidation, rely heavily on gut health. High beta-glucuronidase activity in the microbiome can undo estrogen detoxification, which is why stool testing and targeted gut support may matter. She also covers nutrients involved in estrogen clearance, including glycine, magnesium, and B vitamins, and explains how compounds like DIM can support Phase 1 liver enzymes.
This video focuses on the detox side of hormone balance. The hormone production and “faucet” piece is coming next.
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