Скачать или смотреть Psychiatrist's Guide to Anxiety Medications: First Line to Last Resort

Moving from first-line SSRI picks like Zoloft and Lexapro to smart augmentation with buspirone, gabapentin and Silexan. CBT, mindfulness and evidence-based psychopharmacology weave through every tip so clinicians prescribe with confidence and patients stay informed.
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00:00:00 Intro: Red Bull vs. Bread Bowls
00:02:27 The Problem with Anxiety Meds
00:04:32 The Importance of a Basic Prescribing Algorithm
00:07:21 First Line: Therapy vs. Meds
00:12:53 Why We Avoid PRN Meds for Anxiety
00:17:17 Buspar, Gabapentin & The "Benzo Bridge"
00:22:25 When to Use SNRIs & Gabapentinoids
00:28:36 Propranolol, Mirtazapine, Wellbutrin & TCAs
00:40:08 End of the Road? MAOIs & Benzodiazepines
00:44:03 The "Hairdryer" Story: Pragmatism vs. Dogmatism in Treatment
00:47:31 Practical Considerations for Benzodiazepine Use & Tapering
00:53:08 Antipsychotics (Avoid) & Lavender
00:57:33 Mindfulness Explained
01:00:18 Don't Forget the Basics: Reduce Caffeine!
01:01:03 Final Takeaways & Recap

In an episode that starts with a debate on the calming effects of a bread bowl versus the aggression of a Red Bull, two psychiatrists pivot to a deep and practical discussion on the clinical approach to anxiety medication. One host confesses his skepticism about the broad criteria for Generalized Anxiety Disorder (GAD), clarifying that while he isn't "anti-anxiety medication," he worries that meds often allow patients to skip the fundamentally more important psychological work.

This sets the stage for the episode's core: a comprehensive, real-world flowchart for prescribing. The doctors lay out a clear algorithm, starting with assessing severity and always prioritizing psychotherapy like CBT when possible. For medication, they begin with SSRIs, debating the merits of Zoloft versus Lexapro due to metabolic pathways and titration flexibility. They detail a typical starting protocol for Zoloft and discuss next steps for partial or non-responders, which includes augmenting with buspirone or gabapentin.

A key point of contention is their shared "anti-PRN" stance. They argue that "as-needed" medications like benzodiazepines can sabotage long-term progress by preventing patients from developing their own coping skills and learning to tolerate discomfort. They explore this through different philosophical lenses—one of Western optimism, the other of Eastern acceptance of suffering.

The conversation covers a wide array of options for treatment-resistant anxiety. They discuss the pros and cons of SNRIs (like venlafaxine), tricyclic antidepressants (imipramine, nortriptyline), and other agents like mirtazapine and bupropion, noting how to tailor choices to specific patient needs like insomnia or comorbid conditions. The discussion also includes gabapentinoids (gabapentin and pregabalin), beta-blockers like propranolol for performance anxiety, and the antihistamine hydroxyzine.

Towards the end of the algorithm, they touch upon last-resort options, including MAOIs and the fraught topic of benzodiazepines. They stress the importance of thorough psychoeducation on risks like dependence, withdrawal, and cognitive side effects before ever starting a benzo. The doctors also cover the use of antipsychotics (which they advise against for primary anxiety) and natural alternatives like Silexan (lavender). The episode concludes by emphasizing the foundational importance of assessing substance use (like caffeine), practicing mindfulness, and always centering treatment on improving function, not just erasing anxiety.