Скачать или смотреть Microarray vs Karyotype: What to Do When Culture Fails

Dr. Purvi Agrawal explains how to interpret an abnormal microarray report using a real case suspected of trisomy 13.

✅ Key points:

Even if karyotype culture fails, microarray can analyze DNA from a single cell.

Abnormal microarray can show:

Duplication (extra DNA, e.g., chromosome 13)

Deletion (missing DNA, e.g., chromosome 18)

When duplication and deletion are seen in different chromosomes, suspect an unbalanced translocation.

Parents can be tested to see if they are carriers of a balanced translocation.

💡 Takeaway: Microarray not only detects deletions/duplications but can indirectly suggest translocations, guiding further parental testing.

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