Скачать или смотреть Ultra-sensitive and specific ctDNA assay for early stage lung cancer

James R. Black, MD, UCL, London, UK, discusses the development of NeXT Personal, a whole genome-based, tumor-informed assay for ultra-sensitive and highly specific circulating tumor DNA (ctDNA) detection. Pre-operative plasma samples from an interim cohort of patients with early-stage lung cancer from the TRACERx (NCT01888601) study were analyzed. ctDNA was detected in 81% of lung adenocarcinoma (LUAD) patients and in 100% of non-LUAD patients. Elevated pre-operative ctDNA levels correlated with poor overall survival and relapse-free survival (RFS) in LUAD patients, and correlated with reduced RFS in non-LUAD patients. It is concluded that the platform provides superior analytic performance and prognostic prediction compared to other clinically-validated assays in non-small cell lung cancer. This interview took place at the European Society for Medical Oncology (ESMO) 2023 Congress in Madrid, Spain.

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