Understanding pharmacokinetics to better dose loop diuretics.

Loop diuretics are one of the commonest medications used in hospitals and outpatient. In this series of lectures, we will understand pharmacokinetics of loop diuretics, pathophysiology of CHF and evidence behind the medications that are used in managing CHF congestion.

References :
1. Principles of pharmacology. Pathophysiologic basis of drug therapy. David Golan. Lippincott Williams Wilkins.
2. Pathophysiology of Diuretic Resistance and Its Implications for the Management of Chronic Heart Failure. Hypertension. 2020;76:1045–1054
3. Diuretic Resistance. Ewout J. Hoorn. Am J Kidney Dis. 2017 Jan;69(1):136-142.
4. Diuretic Treatment in Heart Failure .David H. Ellison . N Engl J Med 2017;377:1964-75.
5. 2022 AHA/ACC/HFSA Guideline for the Management of Heart Failure: A Report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines.
6. Diuretic Therapy for Patients With Heart Failure JACC State-of-the-Art Review. JACC VOL. 75, NO. 10, 2020.
G. Michael Felker.


Disclaimer:
This video is not intended to provide assessment, diagnosis, treatment, or medical advice; it also does not constitute provision of healthcare services. The content provided in this video is for informational and educational purposes only.
Please consult with a physician or healthcare professional regarding any medical or mental health related diagnosis or treatment. No information in this video should ever be considered as a substitute for advice from a healthcare professional.
Unless otherwise specified, these lectures are intended only for adult population and may not apply to pediatric/neonates.