Скачать или смотреть Reproductive System | Fertilization

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Ninja Nerds!
In this embryology lecture, Professor Zach Murphy guides you through fertilization, the first step in human development. This lecture breaks down the cellular and molecular events that occur when a sperm cell successfully penetrates a secondary oocyte, forming a genetically distinct zygote.

We begin by exploring the sperm's journey through the female reproductive tract, detailing the processes of capacitation and the acrosomal reaction that allow for penetration of the corona radiata and zona pellucida. Zach then explains the mechanisms preventing polyspermy, including the cortical reaction, and highlights the fusion of male and female pronuclei to complete fertilization.

You’ll also learn the precise timing and location of fertilization, its role in restoring diploidy, and how this single event triggers a cascade of developmental milestones—including the first mitotic divisions that lead to cleavage and blastocyst formation.

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