Скачать или смотреть Imbalances in the retinal microenvironment

Imbalances in the retinal microenvironment can exacerbate the underlying genetic defects in RP and accelerate disease progression. For example:

1. Oxidative stress: Increased oxidative stress due to factors like high oxygen demand, light exposure, and impaired antioxidant defenses can damage retinal cells and worsen RP.

2. Inflammation: Chronic inflammation in the retina, either due to immune dysregulation or cellular stress, can contribute to photoreceptor death and accelerate RP progression.

3. Metabolic dysregulation: Dysfunctions in metabolic pathways within retinal cells can impair their ability to generate energy and maintain cellular homeostasis, thereby exacerbating RP.

4. Extracellular matrix changes: Alterations in the extracellular matrix surrounding retinal cells can affect their structural integrity and signal transduction, influencing RP pathogenesis.

5. Neurovascular interactions: The intricate interactions between neurons, glial cells, and blood vessels in the retina are crucial for its function. Disruptions in neurovascular coupling or blood flow regulation can impact retinal health and exacerbate RP.

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