Скачать или смотреть Immune and barrier dysfunction-related proteomic signatures in Crohn’s disease

To cite: Leibovitzh H, Lee S, Raygoza Garay JA Crohn’s and Colitis Canada (CCC) Genetic, Environmental, Microbial (GEM) Project Research Consortium, et al. Immune response and barrier dysfunction-related proteomic signatures in preclinical phase of Crohn’s disease highlight earliest events of pathogenesis. Gut 2023;72:1462-1471.

Read the full article here: http://dx.doi.org/10.1136/gutjnl-2022...

Objective: The measure of serum proteome in the preclinical state of Crohn’s disease (CD) may provide insight into biological pathways involved in CD pathogenesis. We aimed to assess associations of serum proteins with future CD onset and with other biomarkers predicting CD risk in a healthy at-risk cohort.

Conclusion: We identified serum proteomic signatures associated with future CD development, reflecting potential early biological processes of immune and barrier dysfunction.