Скачать или смотреть 💊H1 Antihistamines Pharmacology USMLE ! First vs Second Generation | Dr. G. Bhanu Prakash

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H1 Antihistamines ! First vs Second Generation | High-Yield Pharmacology for USMLE

💊 H1 Antihistamines are among the most tested and clinically applied drug classes in pharmacology, especially important for NEET PG, FMGE, and USMLE exams! In this high-yield session, we break down the pharmacology of first-generation (e.g., Diphenhydramine, Promethazine, Meclizine, Doxylamine) and second-generation (e.g., Loratadine, Cetirizine, Fexofenadine) antihistamines — covering their mechanism of action as H1 receptor antagonists/inverse agonists at Gq-coupled receptors. 🧬 Understand how they block histamine-mediated effects like vasodilation, edema, bronchoconstriction, and mucus production, making them vital in treating allergic rhinitis 🤧, anaphylaxis 🧯, pruritus 🧴, motion sickness 🚢, nausea 🤢, and even insomnia 😴. We also discuss the critical differences — first-generation drugs cross the blood-brain barrier causing sedation and CNS effects, while second-generation agents are non-sedating due to poor CNS penetration. 🧠

You’ll also learn about side effects like anticholinergic toxicity (dry mouth, urinary retention, tachycardia 🚽💓), anti-alpha adrenergic effects (postural hypotension ⚠️), and contraindications such as BPH and angle-closure glaucoma. 🚫 Bonus insight: why antihistamines are ineffective in hereditary angioedema attacks, and how to approach clinical MCQs where antihistamines are used as antiemetics, anti-allergic agents, or sedatives. Perfect for revision, rapid recall, and conceptual clarity — all packed into one concise video! 🎯📚

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