Vitamin B1-Thiamin(e) Deficiency-----So many symptoms!--Part 1

Vitamin B1-Thiamin(e) Deficiency-----So many symptoms!--Part 1

Dr. Derrick Lonsdale
“It is a critical and rate-limiting co-factor to multiple enzymes involved in this process, including those at the entry points and at critical junctures for the glucose, fatty acid, and amino acid pathways.”

“thiamine availability dictates molecular oxygen homeostasis and mitochondrial ATP production.”

Thiamin dependent enzymes: there are more than the 5 listed.
1. Transketolase
2. Pyruvate Dehydrogenase Complex
3. 2-Hydroxyacyl-CoA Lyase
4. Branched Chain Keto-Acid Dehydrogenase
5. Alpha-Ketoglutarate Dehydrogenase Complex

Recommended daily intake men 1.2 mg and women 1.1mg

B vitamins are water-soluble, so they dissolve quickly in the body. Half life 1-12 hours with approx. 30 mg stored muscle, heart, brain, liver and kidneys which can be depleted in 2-3 weeks. Or with acute illness it can be depleted in as little as 72 hrs. Absorbed in the jejunum of the small intestine by diffusion.

Thiamin deficiency is rare in the US but sub-optimal levels are quite common. True deficiency is called Beri Beri which cause damage to nerves, muscles and cardiovascular system.
Wet beri beri-cardiovascular system(shortness of breath, tachycardia) and edema
Dry beri beri-nervous system, N/T in hands and feet, confusion, memory loss, trouble moving the legs and pain.

Wernicke-Korsakoff Syndrome-alcoholics, malabsorption, anorexia

http://www.mayoclinic.org/drugs-suppl...
http://www.mayoclinic.org/drugs-suppl...
https://ods.od.nih.gov/factsheets/Thi...
http://lpi.oregonstate.edu/mic/vitami...
http://umm.edu/health/medical/altmed/...
http://www.ncbi.nlm.nih.gov/books/NBK...
https://pubmed.ncbi.nlm.nih.gov/22116...
https://www.mdpi.com/2073-4409/10/10/...
https://www.researchgate.net/figure/B...
https://pubmed.ncbi.nlm.nih.gov/15328...

Dr. Jin Sung is a Chiropractic Physician who specializes in the management of complex chronic conditions in Massachusetts, 30 minutes north of Boston. He utilizes natural and alternative therapies to help manage complex cases such as Hashimoto's, autoimmune conditions, IBS, SIBO, chronic fatigue, brain fog, early Alzheimer's, etc.

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The content of this video is for educational purposes only and does not constitute medical advice. Please consult with your physician before embarking on any dietary changes or taking any nutritional supplements.