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endTB-Q first trial

The endTB consortium has completed endTB-Q, the first Phase 3 randomized controlled trial to exclusively enroll people suffering from pre-extensively drug-resistant tuberculosis (pre-XDR-TB), a very hard-to-treat form of tuberculosis (TB).

The trial, conducted by the endTB consortium (Médecins Sans Frontières, Partners In Health, and IRD), demonstrated that a shorter treatment strategy than the conventional treatment and comprised of a combination of four drugs—bedaquiline, clofazimine, delamanid, and linezolid (BCDL)—achieved high cure rates overall and especially good results in the population with non-severe cases of the TB disease.

Clinical trial participants and investigators from India, Kazakhstan and Vietnam share their experiences.

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Médecins Sans Frontières (MSF) is an international, independent, medical humanitarian organisation that delivers emergency aid to people affected by armed conflict, epidemics, natural disasters and exclusion from healthcare.

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