Label-Free Quantification of Chemotherapeutic Cytotoxicity in Glial Cells

Glioblastoma multiforme (GBM) is a malignant brain tumor with a poor prognosis. To advance effective chemotherapies, it's crucial to develop more translational models and advanced quantitative methods that provide deeper insights into cytotoxic effects in a non-invasive manner.

In this presentation, Jasmine Trigg a Scientist from Sartorius, demonstrates use of the Incucyte Live-Cell analysis system and its integrated software to assess the cytotoxic effects of clinically relevant chemotherapeutics on glial cell types.

Learn more: https://www.sartorius.com/en/products...
 
Chapters:
00:28 Here we demonstrate a robust in vitro assay and integrated software to assess cytotoxic effects of clinically relevant chemotherapeutics in glial cell types
01:31 Incucyte®️ Live-Cell Analysis Solutions
04:03 AI-Driven Live/Dead Classification
05:30 Chemotherapeutic Cytotoxicity Screen
07:11 Comparing Concentration-dependent Cytotoxicity in GBM Cells
08:23 Combined Approach to Quantify Cell Death in Microglia
10:31 Live-cell imaging enables acquisition of HD phase contract images

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#Incucyte #LiveCellAnalysis #GBM #Cytotixicity #Glial