GDX - Understanding the Neuroendocrine System: A Novel Approach to HPA Axis Dysfunction

Presented by Dr. Christopher Mote

Dr. Mote specializes in the stress response, circadian rhythm, and sleep optimization for optimal
health. Since 2001, he has been teaching on salivary hormone testing, offering unique
perspectives on adrenal health assessment. Cortisol serves as a surrogate marker for the
body’s stress response. He describes the Cortisol Awakening Response (CAR) as “a stress test
for the brain and its capacity to organize a stress response.”

The limbic system is intimately related to HPA axis function and if understood can make
treatment of stress-related disorders far more effective. Daily stress triggers the "fight or flight"
response, releasing cortisol. However, chronic stress can disrupt the HPA axis, leading to health
issues. This webinar will explore the Limbic system’s influence on HPA axis function and sex,
sleep, and stress hormones, focusing on CAR as a key indicator of HPA resilience. Attendees
will learn how measuring CAR and daily cortisol rhythms helps clinicians identify and address
stress-related imbalances.

Key takeaways:
● Gain a deeper understanding of the Limbic system’s influence on HPA Axis and down
stream hormones
● Learn to interpret 4-point salivary cortisol in the context of CAR
● Review treatments for the HPA axis that help to improve the overall hormone landscape,
● Including neurotransmitter support for abnormal CAR

About Dr. Mote: Dr. Christopher Mote is a dual degreed, Board Certified Family Medicine Physician, specializing in Functional Medicine and Lifestyle Medicine. He graduated from Midwestern University and completed his Family Medicine Residency at Resurrection Hospital. Dr. Mote also earned a Doctor of Chiropractic Medicine from National University of Health Sciences. Dr. Mote is also IFM certified in Functional Medicine, a powerful diagnostic methodology for uncovering the root cause of chronic illness. Having “a foot in each camp” has allowed him to see the potential to help patients through both lenses. He is a regular contributor to Functional Medicine podcasts and clinically trains other physicians in Functional Medicine.