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Pharmacology reveals that some drugs, despite a short lifespan in the bloodstream, can produce effects lasting far longer than their plasma half-life. This phenomenon, explained by understanding what is meant by HIT and run drugs, highlights a critical distinction between a drug's presence in the body and its sustained therapeutic impact.

Quick Summary
A hit and run drug has a short plasma half-life but produces a prolonged effect, often due to irreversible inhibition of its target. The pharmacological action lasts until the body creates new enzymes or receptors.

Key Points
Irreversible Binding: 'Hit and run' drugs permanently or near-permanently inhibit their target (enzyme or receptor) with a covalent bond.

Prolonged Effect: The drug's therapeutic action lasts significantly longer than its plasma half-life.

Short Half-life: These drugs are often eliminated from the bloodstream quickly, within a matter of hours.

Effect Duration Tied to Tissue Turnover: The long-lasting effect depends on how quickly the body synthesizes new, functional target molecules.

Clinical Implications: Less frequent dosing is often possible, but managing long-lasting side effects or overdose is a challenge.

Examples: Common examples include proton pump inhibitors (omeprazole), aspirin, and certain monoamine oxidase inhibitors (MAOIs).
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