Скачать или смотреть KPC肝内胆管癌小鼠（Pten gene，上海开嘉生物）

该KPC肝内胆管癌小鼠模型种包含三个基因： Alb-Cre, pten和K-rasG12D。Pten可以处于纯合子或者杂合子状态。但是，当Pten是杂合子时肿瘤的病理呈多样性，HE鉴定结果可以是肝癌，可以是肝内胆管癌，也可以是混合型肝癌。Pten纯合子时，病理结果必定是肝内胆管癌，小鼠在4周开始发病。所有小鼠都伴有腹血腹水，生存周期不多余12周。The KPC mouse model for intrahepatic cholangiocarcinoma (ICC) incorporates three genes: Alb-Cre, Pten, and K-rasG12D. The Pten gene can exist in either a homozygous or heterozygous state. When Pten is heterozygous, the tumor pathology exhibits diversity; hematoxylin and eosin (HE) staining results may reveal hepatocellular carcinoma (HCC), intrahepatic cholangiocarcinoma (ICC), or mixed-type liver cancer. In contrast, when Pten is homozygous, the pathology is consistently intrahepatic cholangiocarcinoma (ICC), with disease onset beginning at 4 weeks of age. All mice in this model exhibit ascites and hemoperitoneum, with a survival period not exceeding 12 weeks.