Скачать или смотреть Michael Kauffman on Cancer, Drug Development and Market Capitalism - #48

Steve and Corey speak with Dr. Michael Kauffman, co-founder and CEO of Karyopharm Therapeutics, about cancer and biotech innovation. Michael explains how he and Dr. Sharon Schacham tested her idea regarding nuclear-transport using simulation software on a home laptop, and went on to beat 1000:1 odds to create a billion dollar company. They discuss the relationship between high proprietary drug costs and economic incentives for drug discovery. They also discuss the unique US biotech ecosystem, and why innovation is easier in small (vs. large) companies. Michael explains how Karyopharm is targeting its drug at COVID-induced inflammation to treat people with severe forms of the disease.

0:00 - Introduction
0:03:52 - Why cancer is so hard to treat
0:08:55 - Developing and testing their approach to treating cancer
0:27:11 - The pace of drugs discovery/target identification
0:35:00 - Capital requirements and raising money for the company
0:51:10 - Government healthcare spending and medical innovation
1:02:00 - Entrepreneurship and risk taking in small v. big companies
1:06:25 - Sharon Schacham’s background
1:12:20 - COVID and the expedited trial process

Michael Kauffman (Bio)
https://www.karyopharm.com/person/mic...

Karyopharm's Publications and Presentations
https://www.karyopharm.com/technology...

The Great American Drug Deal: A New Prescription for Innovative and Affordable Medicines by Peter Kolchinsky
  / the-great-american-drug-deal  

man·i·fold /ˈmanəˌfōld/ many and various.

In mathematics, a manifold is a topological space that locally resembles Euclidean space near each point.

Steve Hsu and Corey Washington have been friends for almost 30 years, and between them hold PhDs in Neuroscience, Philosophy, and Theoretical Physics. Join them for wide ranging and unfiltered conversations with leading writers, scientists, technologists, academics, entrepreneurs, investors, and more.