Скачать или смотреть The Fall and Rise of Microbiome Diagnostics | Darshit Patel

In this talk, Darshit Patel, Co-founder and CEO of Decode Age, takes a candid look at the current state of microbiome diagnostics—why reproducibility has been a major challenge, how technical and digital contamination have distorted results, and why many AI-driven disease predictions built on microbiome data have fallen short.

Drawing from real examples, retracted studies, and Decode Age’s own journey, he explains how inconsistencies in sample handling, sequencing platforms, bioinformatics pipelines, and reference databases have limited clinical trust in microbiome testing. Darshit outlines how his team stepped back from rapid commercialization to fix these foundational issues, focusing on standardized lab protocols, robust validation, and reproducible pipelines.

The talk concludes with how this rebuilt foundation is enabling more reliable clinical research—from inflammation and gut–brain axis studies to cancer therapy response and precision microbiome interventions—highlighting what it will truly take for microbiome science to contribute meaningfully to aging, longevity, and preventive health.

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