Скачать или смотреть Substance Abuse and the Brain: Gaining a Better Understanding.

In this episode, we dive into the complex world of substance abuse and its profound effects on the brain and our responses. We discuss the addictive loop people fall into with substances like opioids and alcohol. Our special guest, Dr. George F. Koob, an internationally recognized expert on alcohol and stress, and Director of the National Institute on Alcohol Abuse and Alcoholism (NIAAA), shares his insights on the neurobiology of alcohol and drug addiction, and introduces us to the concept of hyperkatifeia. As NIAAA Director, Dr. Koob oversees a broad portfolio of alcohol research ranging from basic science to epidemiology, diagnostics, prevention, and treatment.

Reference: Koob GF. Neurobiology of Opioid Addiction: Opponent Process, Hyperkatifeia, and Negative Reinforcement. Biol Psychiatry. 2020 Jan 1;87(1):44-53. doi: 10.1016/j.biopsych.2019.05.023. Epub 2019 Jun 12. PMID: 31400808.

Timelapse:
00:00 Introduction
01:52 How long has he been researching this topic?
02:38 Stages of opioid addiction
07:56 Physical pain vs. emotional pain
11:46 Where do hyperalgesia and hyperkatifeia intersect?
16:52 What is the brain's response to staying in the addiction loop?
24:14 What are the differences between men and women?
26:16 How does this knowledge help improve treatment strategies?

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Disclosure:
The content of this podcast is purely academic in nature and is intended for educational and informational purposes only. The material discussed does not represent or reflect the views, opinions, or policies of the Medical College of Georgia, and the information presented should not be construed as medical advice or guidance. Always consult with a qualified healthcare professional for any medical concerns or questions. I'd like to explicitly state that I have no endorsement from, affiliations with, or financial interests in any pharmaceutical companies or medical device manufacturers. Any mention of medications, devices, or treatments is made solely within the context of literature and academic discussion.