Скачать или смотреть University of Minnesota Legends in Pathology: Dr. Harry Orr

Dr. Orr is professor and the James Schindler and Bob Allison Ataxia Chair in Translational Research in the Department of Laboratory Medicine and Pathology, directs the Institute of Translational Neuroscience, and is a member of the Division of Molecular Pathology and Genomics. His research is focused on the molecular genetics of neurodegenerative diseases, principally the autosomal dominant form of spinocerebellar ataxia (SCA1). Orr and his colleagues cloned the SCA1 gene and found that the disease is caused by the expansion of an unstable, repeated cytosine-adenine-guanine (CAG) sequence in DNA. The length of the trinucleotide repeat is associated with when symptoms develop. Orr and colleagues are currently exploring molecular approaches to treating patients with SCA1.