Linkage disequilibrium | Introduction to genomics theory | Genomics101 (beginner-friendly)

We continue the beginner-friendly lecture series introducing basic concepts in #genomics, with a focus on single nucleotide polymorphism (#SNP) data.
This time it is about #linkageDisequilibrium (or often abbreviated as LD). This is a very important concept in its own right, revealing the population history and selection pressures acting on populations. LD is also important in many other applications in genomics (some of these will be discussed in the follow-up videos).

There was a lot of stuff published on this channel about LD, for both theory and practice. Here is the playlist with the most important videos:    • Linkage disequilibrium (LD)  

Playlist with the full videos:    • Introduction to Genomics - course  
All PowerPoint presentations are available at: https://github.com/GenomicsBootCamp/I...

Parts of the video:
0:00 - Summary from previous lectures
2:03 - General definitions and comparison to Mendelian rules
8:51 - LD block structure
12:17 - Importance of LD in genomics
16:05 - LD and genetic distance
17:38 - disequilibrium coefficient (D and D') as metric of LD
24:35 - Correlation (r2) as a metric of LD
30:53 - Summary of the lecture

Image source in thumbnail: https://www.pexels.com/photo/starry-s...

Support the channel
*******************************************
To support the Genomics Boot Camp channel, check out the associated site for genotyping services covering companion animals, livestock and more: https://azdatasolutions.eu/