Solutions to Prevent Early Death in Bipolar Disorder with Dr. Melvin McInnis

People with bipolar disorder are four to six times more likely to die prematurely compared to those without a psychiatric disorder. (In comparison, smokers are two to three times more likely to have a shortened lifespan.) There are several contributing factors, including things like metabolic dysfunction, as well consequences of lifestyle choices influenced by disease burden Science needs to urgently investigate these extremely poor outcomes in search of more effective interventions that will enhance quality of life for people with bipolar disorder. Emerging evidence and clinical experience indicate that ketogenic and metabolic therapies may have a central role in addressing this concerning trend.

Dr. Bret Scher interviews Dr. Melvin McInnis, Professor of Bipolar Disorder and Depression at University of Michigan, on these pressing topics. Dr. McInnis is working on a pilot trial that will look at a “ketogenic mimicking diet,” augmenting a low carb diet with exogenous ketones in bipolar disorder. Could this address unwanted metabolic dysfunction in this population? We applaud Dr. McInnins and his team for asking the question.


Experts in this video:
Melvin McInnis, M.D., FRCPsych
https://medicine.umich.edu/dept/psych...
https://medicine.umich.edu/dept/prech...

Study
The Heinz C. Prechter Longitudinal Study of Bipolar Disorder
https://www.ncbi.nlm.nih.gov/pmc/arti...

If you or a loved one are looking to begin ketogenic therapy for a psychiatric condition, visit this page for resources:
https://www.metabolicmind.org/familie...

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About us:
Metabolic Mind is a non-profit initiative of Baszucki Group working to transform the study and treatment of mental disorders by exploring the connection between metabolism and brain health. We leverage the science of metabolic psychiatry and personal stories to offer education, community, and hope to people struggling with mental health challenges and those who care for them.

Our channel is for informational purposes only. We are not providing individual or group medical or healthcare advice nor establishing a provider-patient relationship. Many of the interventions we discuss can have dramatic or potentially dangerous effects if done without proper supervision. Consult your healthcare provider before changing your lifestyle or medications.


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0:00 Introduction
2:12 Dr. McInnis' interest in bipolar disorder
4:11 About Dr. McInnis' study
7:11 How many people were included in the study?
8:25 Why do people with bipolar disorder have a risk of early death?
16:35 Arrhythmias in bipolar disorder
18:23 What isn't associated with premature death in bipolar disorder?
21:35 Ketogenic diet for bipolar disorder
25:53 The need for a support team during ketogenic therapy
26:51 How do depressive symptoms impact early death in bipolar?
29:13 GLP-1 agonists in psychiatry
32:21 What is needed to implement ketogenic therapy in a clinical setting?
37:13 Dr. McInnis' ketogenic therapy study
40:37 Conclusion