Скачать или смотреть Kavli Exploration Award | Mechanisms of brain resilience and adaptation to heat

As climate change leads to more frequent and severe heatwaves, humans and animals must cope with heat stress. Florence Kermen at University of Copenhagen aims to analyze the brain’s molecular, cellular, and circuit-level mechanisms for resilience to heat stress in zebrafish, a cold-blooded animal whose body temperature closely tracks that of the environment. Kermen and her team will examine how specific cells in the brain, neurons, and astrocytes, respond to heat - and then test whether changing astrocyte activity affects the fish’s ability to handle heat. The study will also characterize molecular changes in the brain that allow organisms to adapt to higher temperatures, which is crucial for many species in a warming world. These findings will have broad implications for how climate change affects behavior and adaptability in cold-blooded animals, particularly teleosts like zebrafish.

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