Скачать или смотреть Nanoscale mathematical modeling of synaptic transmission... - 11 October 2018

http://www.crm.sns.it/event/423/
Nanoscale mathematical modeling of synaptic transmission, calcium dynamics, transduction and cell sensing

Advances in high-precision sensing and imaging have emphasised the spatio-temporal nature of information transfer through signal transduction pathways. The compartmentalisation of signalling molecules and the existence of micro-domains are now widely acknowledged as key features in cell signalling. To complement experimental observations of spatio-temporal dynamics, mathematical modelling and analysis have emerged as a powerful tool. Using modelling, one can not only recapitulate experimentally observed dynamics of signalling molecules, but also gain an understanding of the underlying mechanisms in order to generate experimentally testable predictions.

We aim to provide introductory tutorials and discuss the application of mathematical modelling and analysis to the spatio-temporal dynamics of signalling pathways.

PROGRAM

Oct 9:30-10:30 O'Shaughness, Ben
"Modeling neurotransmitter release: Ca sensing, unclamping, and activation of the membrane fusion machinery"

10:30-11:00 Coffee break

11:00-12:00 Heinrich, Doris
"Spatio-temporal control of cell dynamics"

12:00-13:00 Basnayake, Kanishka
"Extreme statistics of fast calcium transients in dendritic spines containing spine apparatus"

15:00-16:00 Heine, Martin
"Dynamics of calcium channel organization in the presynaptic membrane "

16:00-16:30 Coffee break

16:30-17:30 Rothman, Jason
"Simulations of synaptic mechanisms using D3D, a Java-based 3D reaction-diffusion simulator that uses finite-difference and Monte Carlo algorithms"