Causes of the onset of Labour | Nursing Lecture

The exact reason for the causes of the onset of labour is unknown but the various theories responsible for that are explained in this video by the trick, "Parturition's Causes Of ONset"

1. Oestrogen peak theory-
- It increases the release of oxytocin from the maternal pituitary.
- Promote the synthesis of myometrial receptors of prostaglandin, oxytocin.
- Prostaglandin synthesizes from decidua & amnion by the lysosomal disintegration.
- Synthesis of myometrial contractile protein, actin & myosin.
- There is a drop in progesterone synthesis by inhibiting the conversion of pregnenolone to progesterone (in the adrenal gland) by fetal production of cortisol.

2. Prostaglandins initiating theory-
-Prostaglandins E2 and F2α are powerful stimulators of uterine muscle activity.
- The site of synthesis is amnion, chorion, decidual cell, myometrium.

3. Oxytocin theory-
-Large oxytocin receptors are present in the fundus in comparison to the cervix which increases at the time of labour & it stimulates the synthesis or release of Prostaglandins E2 and F2α from amnion & decidua.

4.Fetal placental theory
Increased cortisol production from the fetal adrenal gland before labour may influence its onset by increasing estrogen and prostaglandin production from the placenta by the activation of the fetal hypothalamic-pituitary-adrenal axis.

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