Depression is a prevalent and serious comorbidity in patients with kidney failure, also known as end-stage renal disease (ESRD). Studies indicate that approximately *20-40%* of ESRD patients experience depression, with some estimates even higher depending on assessment methods . The condition is often underdiagnosed due to overlapping somatic symptoms (e.g., fatigue, sleep disturbances, appetite changes) between depression and kidney failure itself .
Depression in ESRD patients is associated with *poorer quality of life**, **increased hospitalization rates**, **treatment non-adherence**, and **higher mortality risk* . Risk factors include advanced age, lower education levels, social isolation, and comorbidities like diabetes and hypertension .
Screening tools such as the *PHQ-9* and *BDI-II* require adjusted cutoff scores in ESRD populations to improve accuracy, though clinical interviews remain the gold standard for diagnosis . Management includes *antidepressants* (SSRIs are often preferred), psychotherapy, and integrated care models addressing both physical and mental health .
Early identification and multidisciplinary support are crucial to improving outcomes in this vulnerable population.
Shafiq Cheema
MBBS(KE), MD (USA), Diplomate American Board Internal Medicine, Diplomate American Board of Nephrology, Fellow American College Physician (FACP), Fellow American College of Nephrology (FASN), Hypertension specialist by ASH...
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Professor Dr. Shafiq Cheema is a Gold Medalist and was the most distinguished Graduate of KEMU, in 1996. He has extensive training & experience in the field of Internal Medicine, Hypertension, and Nephrology. He is a Diplomat American Board of Internal Medicine and Nephrology as well as a Fellow of the American College of Physicians and American Society of Nephrology. He is a renowned Hypertension specialist by ASH. He was lately appointed as Professor of Nephrology at AIMC-Jinnah Hospital. He is amongst America’s top Nephrologists and the world's leading physician. He is the Founder & Patron in Chief of Pak Kidney Foundation (PKF), Chairperson MD Nephrology UHS, and Founder of NephChat with Dr. Shafiq Cheema, providing valuable awareness through YouTube videos related to different diseases. He has worked extensively in the USA in senior positions, including, as former Medical Director of FMC North America, USA, Former Assistant Professor UTHSC Texas, Former Chief of Medicine LMC Texas.
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