Скачать или смотреть Cognitive Enhancers and the Neuropsychological Science of Memory with Steven Roodenrys

In this episode, David interviews Steven Roodenrys, Ph.D. in cognitive psychology.

They talk about the history, demographics of users, efficacy, safety, and effects of nootropics such as Bacopa Monnieri (Brahmi), Caffeine, Glucose, and Ginkgo Biloba.

Audio version of this podcast -   / nineteen  

Show notes:
00:00 - 00:12 Intro
00:12 - 01:13 Steven Roodenrys - Who is he, what’s his history, and what does he do?
01:13 - 15:16 Short-term memory and working memory
How it is tested in neuropsychological research
How it is defined in cognitive neuroscience
What words are we more likely to remember short-term?
How long-term memories and problem-solving skills influence short-term memory performance
15:22 - 18:23 History of use of cognitive enhancers and nootropics
Traditional Chinese Medicine
Caffeine, Cocaine in Coca Cola, and Stimulants
18:24 - 23:23 Current demographics of use of nootropics
More research needed
30-40% of population use supplements
Primarily students, ill, and elderly
23:23 - 32:22 What’s the level of evidence of the efficacy of nootropics?
Inconsistent findings
Individual variance in response to nootropics
** From big negative, to neutral, to big positive effects, from the same compound in the same study
** Biochemical factors influencing how an individual responds:
*** Microbiome
*** Absorption, Distribution, Metabolism, and Excretion
Genes
**** Joe Cohen Nootralize Podcast Interview [https://nootralize.com/personalized-s...]
** Personalized Medicine
*** Promising but still in its infancy
32:31 - 46:34 Bacopa Monnieri (Including Steven's Research)
Steven Roodenrys. et al. (2001). Chronic Effects of Brahmi (Bacopa monnieri) on Human Memory. [https://www.nature.com/articles/1395862] Nature.
What is statistical significance?
** Disproving the null hypothesis. Showing that there probably isn’t no effect.
** Bacopa works for learning (studying), not other memory functions
*** Significant positive effect on Auditory Verbal Memory Test
*** Hippocampal neurogenesis seen in rat studies
46:55 - 01:03:11 Which nootropics have the most evidence backing their efficacy and safety?
Nootropics with proven acute/short-term cognitive benefits - Beware of tolerance, addiction, and other risks (e.g. anxiety)
** Caffeine (100mg+) for alertness, concentration, and learning
** Glucose (25g+) for memory
** Other stimulants (e.g. Amphetamines)
Nootropics with proven chronic/long-term cognitive benefits
** Anthocyanins (e.g. from blueberries)
** Bacopa Monnieri - Hippocampal neurogenesis
We need more research. It could be that supplements are much more useful to people who don’t already, sleep, exercise, and eat well.
01:03:14 Outro
The Nootralize App - https://beta.nootralize.com
01:04:52 End

Contact Steven Roodenrys: [email protected]

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