Is boosting NAD+ with NMN or NR the key to slowing aging, boosting energy, and improving health... or just overhyped? In this video, we break down the science behind NAD+ decline with age (up to 50% by 50), how precursors like NMN and NR raise levels, key human trials and reviews from 2023-2025 (including meta-analyses on metabolic benefits, safety up to 3,000mg, and mixed but promising results on cognition, recovery, and mitochondrial function), benefits for ATP, DNA repair, sirtuins, brain health, insulin sensitivity, neuroprotection, and why it's not a miracle. We cover dosing, side effects, expert views (like Dr. Brad Stanfield and David Sinclair), and the real verdict for folks over 40 feeling fatigue or slowdowns. Evidence-based and relatable – perfect for biohackers!
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Key Citations
• Efficacy of oral nicotinamide mononucleotide supplementation on glucose and lipid metabolism for adults: a systematic review with meta-analysis on randomized controlled trials. https://www.tandfonline.com/doi/full/...
• Effects of nicotinamide riboside on NAD+ levels, cognition, and symptom recovery in long-COVID: a randomized controlled trial. https://www.thelancet.com/journals/ec...
• Use of the Dietary Supplements NR and NMN to Increase Nicotinamide Adenine Dinucleotide, Impact Mitochondrial Function, and Improve Metabolic Health. https://www.mdpi.com/3042-5158/1/2/9
• The role of NAD+ metabolism and its modulation of mitochondria in aging and disease. https://www.nature.com/articles/s4432...
• Chronic nicotinamide mononucleotide supplementation elevates blood nicotinamide adenine dinucleotide levels and alters muscle function in healthy older men. https://www.nature.com/articles/s4151...
• Nicotinamide adenine dinucleotide metabolism and arterial stiffness after long-term nicotinamide mononucleotide supplementation. https://www.nature.com/articles/s4159...
• NR-SAFE: a randomized, double-blind safety trial of high dose nicotinamide riboside in Parkinson's disease. https://www.nature.com/articles/s4146...
⚠️DISCLAIMER This video is for informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always consult your healthcare provider before starting any new supplement, diet, or health regimen—especially if you have existing conditions or take medications. Laura Armstrong is not a medical professional. The content reflects personal opinions, research, and experiences and should not be taken as medical advice. No claims are made regarding the treatment or cure of any condition. Use this content at your own risk. Individual results may vary. By watching this video, you agree to hold Laura Armstrong and her representatives harmless for any loss, injury, or damage resulting from its use.
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