Oxygen Hemoglobin Dissociation Curve - Comprehensive and Clear Explanation!

The Oxygen Hemoglobin Dissociation Curve, also known as the Oxyhemoglobin Dissociation Curve, is a critical concept. Understanding this provides a foundation for a number of pathophysiologic processes key in the understanding of physiology.

In this video, we dive into these concepts. We start by discussing what makes up oxygen content in the blood and how that differs between the arterial system and venous system. We discuss gas exchange of oxygen and carbon dioxide at the capillary level. We then define key concepts like oxygen content (with the equation), dissolved oxygen (PaO2), oxygen saturation (SaO2, SpO2). We dive into red blood cells, hemoglobin (subunits), oxygen binding capacity of hemoglobin, tense vs relaxed states, tissue-lung interface, and more. After that, we use all of these concepts to establish what the normal oxyhemoglobin dissociation curve is before discussing abnormal including left shifts, right shifts, Bohr's Law, and more!

Introduction to Capillary Gas Exchange, Arterial vs Venous Systems, Oxygen Content: 0:00 - 6:11
Defining Oxygen Content, Oxygen Saturation (SaO2, SpO2), Dissolved Oxygen (PaO2): 6:12 - 12:48
Red Blood Cells, Hemoglobin Structure (subunits), Oxygen Binding Capacity, Tense vs Relaxed, Lung Tissue Interface: 12:49 - 20:01
Relationship Between SaO2 (SpO2) and PaO2 or Oxygen Saturation and Dissolved Oxygen: 20:02 - 24:17
Normal Oxyhemoglobin Dissociation Curve: 24:18 - 28:54
Right Shift, Left Shift, Bohr's Law, Bringing it all Together: 28:55 - 37:35

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DISCLAIMER THIS VIDEO DOES NOT PROVIDE MEDICAL ADVICE. The information, including but not limited to, text, graphics, images and other material contained on this website are for informational purposes only. No material on this site is intended to be a substitute for professional medical advice, diagnosis or treatment. Always seek the advice of your physician or other qualified health care provider with any questions you may have regarding a medical condition or treatment and before undertaking a new health care regimen, and never disregard professional medical advice or delay in seeking it because of something you have read, watched, or listened to on this video, or any other videos, reports, texts tweets or other sources.

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