Скачать или смотреть Size Selection of Cell-free DNA Increases the Proportion of Tumor Specific Variants in Cancer...

Presented By: Kimberly Holden

Speaker Biography: Kimberly Holden is currently a Research Associate III at Labcorp in San Diego, CA where she works in oncology diagnostics assay development. She has investigated genomic instability in circulating tumor DNA to predict response to treatment and outcome in metastatic breast cancer patients. Additionally, she has explored using genome-wide sequencing of cell-free DNA to detect copy number alterations in cancer patients where tissue biopsy is not feasible. She is interested in studying the effect of size selection of cell-free DNA to improve the detection of tumor-specific variants in cancer patients. Kimberly received her M.S. in Integrative Biology from the University of Wisconsin – Madison in 2015 where she studied population genetics and hybridization between two species of Australian birds.

Webinar: Size Selection of Cell-free DNA Increases the Proportion of Tumor Specific Variants in Cancer Patients

Webinar Abstract: The proportion of cell-free DNA (cfDNA) derived from tumor cells in the plasma of patients with cancer is typically less than 2%. To overcome this limitation, methods have been developed to better distinguish the circulating tumor DNA (ctDNA) signal from the noise we encounter in most current methodologies. While these solutions are successful in minimizing the technical noise, it often requires increased sequencing depth and other advanced analytical techniques. Thus, alternative or complimentary approaches, such as liquid biopsies, would be beneficial for improving noninvasive cancer diagnostics.

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