Paraneoplastic etiology of myeloneuropathy

Divyanshu Dubey, MBBS, Mayo Clinic, Rochester, MN, discusses the findings of an observational study of myeloneuropathy in paraneoplastic neurologic syndromes (PNS). PNS are a group of neurological disorders resulting from autoimmune responses mounted against the nervous system during an antitumor immune response. To determine if myeloneuropathy is a presenting phenotype of PNS, disease features of 32 patients with myeloneuropathy and underlying cancer or onconeural antibody seropositivity were investigated. The study concluded that paraneoplastic etiologies should be considered when evaluating myeloneuropathies, as well commonly considered metabolic etiologies. This interview took place during the ACTRIMS Forum 2021.