Скачать или смотреть Altogen Labs HEK-293 Xenograft Service Kidney Cancer

Altogen Labs http://altogenlabs.com provides xenograft services http://altogenlabs.com/xenograft-mode.... Human embryonic kidney cells are frequently used in cancer research as well as for pharmaceutical and biomedical purposes. The HEK-293 cell line is isolated from human embryonic kidney cells through the transformation with sheared adenovirus 5 DNA and involves the incorporation of the viral genome into human chromosome 19. HEK-293 cells are particularly helpful for producing therapeutic proteins and viruses for gene therapy. Also, the HEK-293 cell line has high transfection efficiency is a valuable tool for a variety of medical applications.
The HEK-293 human kidney cell line is used to create the CDX (Cell Line Derived Xenograft) HEK-293 xenograft mouse model, a highly utilized CDX in kidney cancer research for studying the anti-angiogenic and anti-tumor efficacy of kinase inhibitors such as sunitinib. The HEK-293 xenograft model is useful for biomedical research related to renal cancer.
Xenografting is the transplantation of tissue from one species into another.
Xenografting has been established as benchmark studies in pre-clinical cancer research.
Typically, immunodeficient mice serve as hosts for a wide variety of human tumors, effectively serving as models for human subjects.
Xenografting is a complete and accurate study of tumor growth and the activity of drug administration.


-HEK-293 Xenograft Model
Sample Cell Lines Available

-HEK-293 Xenograft Model
Advantages of Xenografting
Develop new therapeutic agents quickly, efficiently and cost-effectively
Evaluate the efficacy and toxicity of potential therapeutic agents
Evaluate target compound activity using in vivo system (human cells)
Predict cytotoxicity of cancer drugs

-HEK-293 Xenograft Model
Basic Xenograft Study
Xenograft studies can be designed to:
Identify lead compounds
Optimize dose schedules
Identify combination strategies

-HEK-293 Xenograft Model
Routes of drug administration:
Intratumoral
Intramuscular
Oral gavage
Intravenous
Intratracheal
Subcutaneous
Intraperitoneal
Continuous infusion
Intranasal
Using cutting-edge micro-injection techniques

-HEK-293 Xenograft Model
Following options are available for the HEK-293 xenograft model:
HEK-293 Tumor Growth Delay (TGD; latency)
HEK-293 Tumor Growth Inhibition (TGI)
Dosing frequency and duration of dose administration
HEK-293 tumor immunohistochemistry
Alternative cell engraftment sites (orthotopic transplantation, tail vein injection and left ventricular injection for metastasis studies, injection into the mammary fat pad, intraperitoneal injection)
Blood chemistry analysis
Toxicity and survival (optional: performing a broad health observation program)
Gross necropsies and histopathology
Positive control group employing cyclophosphamide, at a dosage of 50 mg/kg administered by intramuscular injection to the control group daily for the study duration
Lipid distribution and metabolic assays
Imaging studies: Fluorescence-based whole body imaging, MRI

-HEK-293 Xenograft Model
Altogen Labs’ team of scientists carries extensive experience in Xenograft model research.
Altogen Labs is compliant as a Good Laboratory Practices (GLP) environment, which is required by the FDA for pre-clinical research.
Our Altogen Labs’ Xenograft services are extensive, rigorous, and flexible.
Contact us to discuss Xenograft model details, timeline estimates, and price quotes!

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