Скачать или смотреть 62: Leptin and Leptin Resistance Explained - Insights from Dr. Ben Bikman

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Dr. Ben Bikman’s lecture on leptin, delivered in his Metabolic Classroom series, highlights the hormone's critical role in metabolism. Leptin, primarily produced by white fat tissue, helps regulate energy balance by signaling the brain to suppress appetite and promoting mitochondrial biogenesis in muscle cells. Leptin levels correlate with body fat, and various factors like insulin and TNF alpha influence its production. Insulin significantly stimulates leptin secretion, highlighting a complex interplay between these hormones.

Leptin resistance, a condition where the body fails to respond effectively to leptin despite high levels, is similar to insulin resistance and often occurs in individuals with higher body fat. This leads to compromised satiety signals, energy expenditure, and potential obesity. Dr. Bikman also explores leptin’s broader effects on reproductive health, thyroid function, immune function, vascular health, and bone formation. These diverse roles underline leptin's significance in the body.

A historical perspective reveals leptin’s discovery in 1994 by Dr. Jeff Friedman’s lab at Rockefeller University. They found that leptin played a crucial role in regulating body weight in mice. However, leptin injections in obese humans did not yield similar results, as most obese individuals already have high leptin levels, leading to the understanding that leptin resistance, not a lack of leptin, is the issue in obesity.

The lecture concludes with practical insights on addressing leptin resistance, emphasizing the importance of controlling blood glucose and insulin levels, particularly through low-carb diets. This approach helps reduce leptin levels and improve leptin sensitivity, offering a pathway to better metabolic health and weight control.

00:00 - Introduction to the Metabolic Classroom
00:53 - What is Leptin?
02:54 - Regulation of Leptin Production
03:59 - Factors Stimulating Leptin Secretion
04:57 - Insulin and Leptin Interaction
06:04 - TNF Alpha and Leptin
08:18 - Steroid Hormones and Leptin in Women
11:31 - Leptin’s Role in Metabolism and Satiety
12:49 - Leptin and Mitochondrial Biogenesis
13:51 - Leptin’s Influence on Reproductive Health
14:57 - Leptin and Neuroendocrine Function
19:04 - Leptin’s Impact on Immune Function
20:13 - Leptin and Vascular Function
21:23 - Interaction Between Leptin and Insulin
23:28 - History of Leptin’s Discovery
27:22 - Leptin Resistance and Obesity
29:24 - Causes of Leptin Resistance
32:44 - Caloric vs. Endocrine Theory of Obesity
34:48 - Hyperleptinemia and Leptin Resistance
37:46 - Addressing Leptin Resistance
38:36 - The Role of Diet in Leptin Sensitivity
39:00 - Conclusion and Final Thoughts

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References:

Insulin Stimulates Both Leptin Secretion and Production by Rat White Adipose Tissue: https://academic.oup.com/endo/article...

In vivo and in vitro evidence for the involvement of tumor necrosis factor-alpha in the induction of leptin by lipopolysaccharide: https://www.semanticscholar.org/paper...

Gender Differences in Both Spontaneous and Stimulated Leptin Secretion by Human Omental Adipose Tissue in Vitro: Dexamethasone and Estradiol Stimulate Leptin Release in Women, But Not in Men: https://academic.oup.com/jcem/article...

Leptin Regulation of Neuroendocrine Systems: https://consensus.app/papers/leptin-r...

Leptin Regulation of Immune Responses: https://consensus.app/papers/leptin-r...

Leptin effect on endothelial nitric oxide is mediated through Akt-endothelial nitric oxide synthase phosphorylation pathway: https://consensus.app/papers/leptin-e...

(Due to YouTube’s character length constraints, not every reference is posted above. For a complete list, email [email protected] with your request.)