Скачать или смотреть How Best to Explore Chemical Space for Bioactive Molecular Discovery | Prof Alan Nelson | Oct 9 2023

Prof Alan Nelson
Professor of Chemical Biology, Department of Chemistry, University of Leeds
Deputy Director, Astbury Centre for Structural Molecular Biology, University of Leeds
9 October, 2023

The discovery of bioactive small molecules is a challenge that is central to both drug discovery and chemical biology. However, given that there may be over 10^30 drug-like small molecules, how can we discover molecules with specific biological functions? The challenge is compounded by chemists' highly uneven and unsystematic historic exploration of chemical space: the reliance of a small toolkit of reactions means that the known chemistry 'universe' is dominated by a small number of structural classes that are found in many different molecules. In his talk, Prof Nelson explains how we draw inspiration from nature to drive the discovery of useful bioactive molecules, using diversity-oriented and activity-directed synthesis approaches.

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