Bioengineered Organ-on-Chip Models of Lymphatic Function and Disease

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Bioengineered Organ-on-Chip Models of Lymphatic Function and Disease

Esak (Isaac) Lee serves as an Assistant Professor in the Department of Biomedical Engineering and holds the title of Nancy and Peter Meinig Family Investigator in the Life Sciences at Cornell University, USA. His research is centered on the development of bioengineered organ-on-chip models that simulate human lymphatic biology, aiming to shed light on the mechanisms underlying lymphatic diseases, immunological disorders, and cancer. Lee's research has been supported by the NIH, with funding from the NHLBI, NCI, and NIAID, where he serves as the principal investigator. He has authored over 40 articles in peer-reviewed journals and has been recognized with awards such as the NSF Career Award (2024), the Cellular & Molecular Bioengineering Young Innovator Award (2023), the Emerging Leader in Biological Engineering Award (2022), the Microcirculatory Society Award for Excellence in Lymphatic Research (2021), and the Lymphatic Education & Research Network (LE&RN) Postdoctoral Fellowship (2016).

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About Lymphatic Education & Research Network (LE&RN):

LE&RN's mission is to fight lymphatic diseases through education, research, and advocacy. We seek to accelerate the prevention, treatments and cures for lymphedema, lipedema, lymphatic anomalies, and the continuum of lymphatic diseases.

About LE&RN

The Lymphatic Education & Research Network (LE&RN) is an internationally recognized non-profit organization founded in 1998 to fight lymphatic disease (LD) through education, research, and advocacy. Lymphatic diseases include lymphedema (LE), lipedema, and lymphatic anomalies. LE&RN is equally committed to investigating preventive and therapeutic benefits for a broad array of diseases that are impacted by lymphatic function, such as heart disease, obesity, AIDS, Rheumatoid arthritis, diabetes, and cancer metastasis.

To accomplish these goals, LE&RN sponsors research fellowship grants, an international patient registry and biorepository, live-stream symposiums, the peer-reviewed journal Lymphatic Research & Biology, weekly e-newsletters, scholarship grants to lymphedema therapists, conference travel awards to young researchers, and a vibrant website with features such as Ask the Experts, connecting patients with the field’s more renowned practitioners. LE&RN has Chapters and Centers of Excellence globally. In 2016, LE&RN created World Lymphedema Day on March 6th, which was established by unanimous vote of the United States Senate.

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