Primary Lateral Sclerosis — Unicorn, Dragon or Other Mythological Beast?

Lauren Elman, M.D., associate professor of neurology at the Hospital of the University of Pennsylvania and Penn Medicine, discusses her research with primary lateral sclerosis (PLS), a rare motor neuron disease often mistaken for ALS. #PrimaryLateralSclerosis #JohnsHopkins https://www.hopkinsmedicine.org/neuro...


CHAPTERS:
2:15 PLS History
6:48 Natural History of PLS
14:31 Clinical Care in PLS
15:37 What’s needed to conduct PLS clinical trials?
18:06 Neuropathology of PLS
27:23 Consensus Diagnostic Criteria
35:32 Neurobiology of PLS
38:19 Genetics of PLS
39:03 Are ALS and PLS part of a spectrum of disease?
40:22 Biomarkers in PLS
43:34 Neuroimaging in PLS
47:24 Measuring PLS Progression
54:16 Clinical Trial Targets — Symptomatic
55:31 Clinical Trial Targets — Disease Modifying
1:03:20 Conclusion