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QQQ vs. HRMS: Which is Better for Impurity X Quantitation?

When it comes to impurity quantitation in pharmaceuticals, choosing the right mass spectrometry method is crucial. In this video, we compare Triple Quadrupole Mass Spectrometry (QQQ) and High-Resolution Mass Spectrometry (HRMS) to evaluate their performance in quantifying Impurity X in a drug product.

We’ll break down key aspects such as:
✅ Selectivity – How well each method differentiates Impurity X from background noise
✅ Linearity – How accurately the instruments respond to different impurity concentrations
✅ Accuracy & In-Matrix Accuracy – Ensuring reliable results in complex sample matrices
✅ Regulatory Alignment – Meeting industry standards for impurity testing
✅ Method Transfer Feasibility – Can you switch between QQQ and HRMS seamlessly?

Both techniques demonstrate strong reliability and flexibility, making method selection dependent on specific analytical needs.

🔬 About Emery Pharma
Emery Pharma is a leading FDA-registered, DEA-licensed, and cGMP-compliant Contract Research Organization (CRO) specializing in analytical chemistry, bioanalysis, microbiology, and mass spectrometry solutions. We provide advanced LC-MS, HRMS, QQQ, NMR, and bioanalytical method development and validation services to pharmaceutical, biotech, and medical device companies worldwide.

📩 Contact Emery Pharma:
🌐 Website: www.emerypharma.com
📧 Email: [email protected]
📞 Phone: +1 (510) 899-8814

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