How Systems Immunology Uncovered a Distinct Phenotype | Leveraging Covalent Approaches | CMGR

Full title - How Systems Immunology Uncovered a Distinct Phenotype of Memory B Cell Holds IgE Memory

Presented by: Dr. Joshua Koenig (0:00)

By the end of the session, participants will be able to:
• “omics” research and how it fosters discovery.
• Defining a novel memory B cell subset expressing markers of type 2
immunity.
• A role for type 2 memory B cells in IgE memory responses and
persistent allergy.

Full title - Leveraging Covalent Approaches For Proximity Induction in Immunotherapy

Presented by: Dr. Anthony Rullo (26:05)

By the end of the session, participants will be able to:
• What is “proximity induction” and how is it leveraged for therapeutic
development?
• Understanding efficacy beyond receptor occupancy-driven
pharmacology
• Understanding modes of action for first-in-class covalent macrophage
and T cell “engager” modalities

0:00 How Systems Immunology Uncovered a Distinct Phenotype of Memory B Cell Holds IgE Memory
26:05 Leveraging Covalent Approaches For Proximity Induction in Immunotherapy

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McMaster University’s, Department of Medicine Grand Rounds (MGR), combined with Hamilton Health Sciences and St. Joseph’s Healthcare Hamilton, is held on rotation every Thursday from 8:00AM - 9:00AM via ‘Zoom’ and uploaded to our channel weekly. Webinar registration for department faculty & residents opens each Tuesday at 9:00 AM.

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We acknowledge with gratitude and respect that McMaster University, Hamilton Health Sciences, and St. Joseph’s Healthcare Hamilton, stand on the traditional territory shared between the Haudenosaunee confederacy and the Anishinabe nations, recognized in the Dish with One Spoon Wampum belt treaty.