Скачать или смотреть Pharmacodynamics part 3

lecture’s Note: https://www.mediafire.com/file/xawr1y...

Time codes
00:20 Variation of drug response
14:52 Tolerance
23:07 Drug Interactions
27:21 Drug Antagonism
41:14 Types of adverse effects
51:55 Factors affecting dose

this interesting video describes Variation in drug response and Types of variation; Hypo-reactive, Hyper-reactive, Tolerance & Idiosyncracy
I. variation in drug concentration reaching the receptors:
II. Variation in the number of the receptors
Receptor Upregulation, Receptor Downregulation
TOLERANCE; It is hyporesponsiveness to the usual dose of the drug.
Congenital tolerance, Acquired Tolerance, Tachyphylaxis "acute acquired tolerance", Cross-tolerance.

Drug interactions; Addition or summation, Synergism, Potentiation & Antagonism. Pharmacokinetic antagonism; Antagonism in absorption, distribution, metabolism and excretion.
Chemical antagonism and Receptor antagonism; Competitive antagonism & Non-competitive antagonism

ADVERSE DRUG REACTIONS
Allergy, Toxic reactions, Iatrogenic diseases, Idiosyncratic drug reactions
Examples of Pharmacogenetic drug response
• Succinylcholine apnea
• Acetylators of isoniazid
Example of idiosyncrasy due to unknown cause
• Malignant hyperthermia with halothane.
• Chloramphenicol-induced aplastic anemia
drug Abuse (addiction, dependence ); Drug abuse may lead to psychological or physical dependence.
Teratogenic effect
it also discusses Factors determining drug dosage, Factors related to patient such as Age, Sex, Diseases, Weight & surface area.

Factors related to drug such as Route of drug administration, Time of administration, Super-sensitivity, Cumulation, Allergic reactions, Tolerance & Tachyphylaxis and Drug abuse.
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