Скачать или смотреть Waardenburg Syndrome Types 1, 2, 3 & 4: High Yield Dermatology Mnemonics (USMLE/NEET PG)

Master the 4 types of Waardenburg Syndrome in just 4 minutes! This high-yield dermatology review covers everything you need for the USMLE Step 1, NEET PG, and board exams.

Waardenburg syndrome is a rare genetic disorder involving the neural crest lineage, causing hearing loss and pigmentary changes. We break down the key differences between PAX3, MITF, and SOX10 mutations.

📚 Video Chapters:
0:00 Introduction to Waardenburg Syndrome
0:19 Type 1: PAX3 Mutation & Dystopia Canthorum
1:02 Type 2: MITF Mutation (No Dystopia Canthorum)
1:51 Type 3 (Klein-Waardenburg): Upper Limb Abnormalities
2:42 Type 4 (Shah-Waardenburg): Hirschsprung Disease link
3:26 Summary: AD vs AR Inheritance
3:54 Key Takeaway: Neural Crest Lineage

✅ High-Yield Facts Covered:
Type 1: PAX3 gene, Dystopia Canthorum (widely spaced eyes), White forelock.
Type 2: MITF gene, More severe deafness, NO Dystopia Canthorum.
Type 3: PAX3 gene, Upper limb/skeletal deformities (contractures).
Type 4: SOX10/EDN3 genes, Hirschsprung Disease (aganglionic megacolon).

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This video is manually designed and edited by a deaf/mute creator using assistive voice technology for educational accessibility.