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What is Maintenance therapy with Lynparza plus Avastin ​| OncoPower

If you're wondering, "What is Maintenance therapy with Lynparza plus Avastin?" then this video is for you. Discover the benefits of using maintenance therapy with Lynparza and Avastin to help better manage ovarian cancer relapse.

#Lynparza #Avastin #OncoPower

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What is Lynparza and Avastin maintenance therapy, and how does it work?

Avastin, also called Bevacizumab, is a targeted therapy treatment. It is a "Monoclonal antibody" that binds or attaches and inhibits or blocks growth factors that are important for new blood vessels to form which can be one of the ways the cancer grows. Therefore, this can stop cancer cells’ growth.
Lynparza, also called Olapraib, is a PARP inhibitor. It inhibits PARP – an enzyme which is involved in DNA repair and thus growth of cells. Lyparza works by blocking Cancer cells from repairing their damaged DNA.

Who gets this regimen:

Please note that this is Maintenance therapy. Maintenance therapy is used for those patients who have already had a response to initial therapy.
This regimen is mainly given as a “maintenance therapy” to patients with ovarian, fallopian tube, or primary peritoneal cancer with

Advanced or stage 4,
-who achieved complete or partial response to first-line platinum-based (Carboplatin) chemotherapy, and
-whose cancer is associated with homologous recombination deficiency positive status defined by either a deleterious BRCA mutation, and/or genomic instability. (This test is done on the tumor specimen.)

How is this regimen given?
· Bevacizumab or Avastin is given through an IV or infusion port. It is administered every three weeks. Each three weeks constitutes a cycle. Each session lasts for about 30-60 minutes. This is usually continued for 1-2 years of maintenance as long as it is tolerated well and there is no progression or regrowth of cancer.

Olaparib or Lynparza tablets are taken twice a day by mouth. This is continued for up to 2 years or until disease worsens or a patient experiences unacceptable side effects. The tablets can be taken with or without food and should be taken at around the same time every day.
Please tell your doctor about any medicines you are taking, including vitamins, herbal supplements and over-the-counter medicines, to make sure they won’t interfere with your treatment.

Feel free to watch this video as many times as you would like or email for the transcript to read.

In Video 2, we will go over some of the common side effects from this treatment and how to manage them at home or by calling your doctor if there are serious side effects.

If you have any additional questions, please call your doctor’s office.


Thank You and Good Luck.