Скачать или смотреть Solid State Foundations | Chapter 6: Screening

Solid Form Screening & Selection — practical workflow to pick the best solid form for your API.
Presented by Clara Pina Coronado, Solid State Scientist & Science Communicator at Solitek.

In this episode of Solid State Foundations (Chapter 6) we walk through the critical steps of screening and selecting the optimal solid form — polymorphs, salts and cocrystals — during drug development. Choosing the right solid form can dramatically improve solubility, dissolution rate, stability and manufacturability, and it can create new IP opportunities.

What you’ll learn in this short video

Why systematic screening & selection matter for APIs and formulations

How to define objectives before screening (performance targets, IP goals, regulatory constraints)

The three preparatory pillars: clear objectives, strategic approach (purify vs. search for new forms), and robust solid-state characterization of the API

Practical screening techniques:

Polymorph screening: solvent crystallization (evaporation, cooling), melt/quench, thermal cycling, desolvation routes

Salt screening: acid/base pairing guided by pKa considerations, target dose & administration route

Cocrystal screening: selection of coformers guided by binding motifs and phase-diagram insights

Common experimental tools: slurry/solution crystallization, liquid-assisted grinding, automated robotics for high-throughput screening

-Key selection criteria: stability (physical/chemical), solubility & dissolution, manufacturability (flow, compressibility), dose & route dependency, and IP/regulatory strategy
-Analytical toolbox for decision-making: XRPD, DSC, TGA, solid-state NMR, microscopy, hygroscopicity (DVS/VSA), and dissolution testing
-How to translate screening results into development decisions and next steps

Why watch: If you’re working on low-solubility compounds, early-stage APIs, or needing to strengthen IP or regulatory positioning, this video gives a clear, practical roadmap for discovering and choosing the best solid form.

👉 Got a tricky solid-state case? Drop your question in the comments or contact Clara at Solitek — we often answer user cases in future episodes.

👍 Like, subscribe, and hit the bell to catch the next Solid State Foundations video — practical lessons for scientists working in solid-state and formulation R&D.

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