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Is It Safe To Take Expired Medicines? | Youtoopedia Studios
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What Does Expiration Date Mean?
The expiration date, required by law in the United States, beginning in 1979, indicated the date the manufacturer guarantees the full potency and safety of the drug. At the time of the medication expiry date, the drug must be at least 90% of the original potency under proper storage conditions.

The expiration date does not indicate a point when a medication loses potency and is no longer effective or becomes harmful.

In general, drugs expiration date is 2-5 years from production date. FDA regulations do not require manufacturers to determine actual long-term drug potency and stability. For example, if a company chooses a three year expiration date, it does not have to test beyond that for prolonged effectiveness.

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POTENCY & EFFICACY
In fact, medication's potency gradually decreases starting from the moment of its manufacture. This process is not in anyway spontaneous after the expiry date.

Expired drugs have not necessarily lost their potency and efficacy. The expiration date is only an assurance that the labeled potency will last at least until that date. Ongoing research shows that stored under optimal conditions, many drugs retain 90% of their potency for at least five years after the labeled expiration date, and sometimes longer. Even 10 years after the expiration date many pharmaceuticals retain a significant amount of their original potency.

Important note: Solid dosage forms, such as tablets and capsules, are most stable past their expiration date. Drugs that exist in solution or as a reconstituted suspension may not have the required potency if used when outdated.
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SAFETY & TOXICITY
Contrary to common belief, there is little scientific evidence that expired drugs are toxic. There are virtually no reports of toxicity from degradation products of outdated drugs.

According to The Medical Letter (2015) the only report of human toxicity that may have been caused by chemical or physical degradation of a pharmaceutical product is renal tubular damage that was associated with use of degraded tetracycline (GW Frimpter et al, JAMA 1963; 184:111). Since then, tetracycline products have been changed to eliminate the problem [2]. The lack of other reports of toxicity from expired medication is reassuring, however expired medication toxicity is not a well-researched field.

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LIQUID MEDICATIONS
Drugs in liquid form (solutions, suspensions) are not as stable as solid dosage forms (tablet, powder, capsule).

Drugs prepared by addition of a solvent before dispensing or administration (such as suspensions of antibiotics for oral use or lyophilized drugs in vials for parenteral use) tend to be relatively unstable in the liquid state. Suspensions are especially susceptible to freezing.

Injectable medications, which have become cloudy or discolored or show signs of precipitation should not be used.

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STORAGE CONDITIONS
Factors that negatively affect drug stability:

light (especially sunlight)
oxygen
moisture
extreme temperatures
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FACTORS TO CONSIDER IN DECIDING WHETHER TO USE AN EXPIRED MEDICINE:
Dosage formulation -- liquids are generally unstable.
Package-type, container closure system.
Storage conditions. Medications do retain their effectiveness longer if they are kept unopened.
Length of time between initial manufacture and final use.
Appearance of medication. Do not use if: tablets are brittle or breaking apart; tablets or capsules have loss of sheen; tablets or capsules are soft; emulsions or suspensions remain separate despite shaking; injectables appear discolored or a precipitate has formed. With aspirin, it's easy to tell if it's "going bad": the stronger aspirin tablets smells, the less effective it is. Never take medicine that seems suspicious in some other way.

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CAN YOU TAKE EXPIRED MEDICATIONS?
The wisdom suggests that if your life does depend on an outdated drug, and you must have 100% of the original strength, it is wise to follow the cliché "better safe than sorry".

If your life does not depend on an expired drug -- such as you have headache, common cold, or constipation -- you may take the medication and see what happens.

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Source: https://www.emedexpert.com/tips/expir...

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