Promise and Controversies: State of the State of Longevity Science with Matt Kaeberlein, PhD

It's important to me to include a variety of voices in the sphere of aging and longevity, and Matt Kaeberlein PhD is certainly one that I appreciate for his tempered and rational arguments. I value his insights and his work with other scientists who are tussling with the challenging questions and research interpretations in this field. We are at this extraordinary inflexion point where scientists are debating the very definition of aging itself, which has important implications for how we then measure and study it. Dr. Kaeberlein shares his thoughts on this as well as the latest on longevity interventions such as rapamycin, metformin, intermittent fasting, and caloric restriction. Find out why he thinks we'll always hit a wall with moving the needle on lifespan, and why healthspan is such an important target. I think you will find this conversation illuminating and useful.

An additional note for any of my listeners/readers who have been tracking the various discussions around the utility of epigenetic clocks and other measures of aging: I personally very much believe in epigenetics, even as the field continues to evolve. The foundation of this traces back to my beginnings in this field, working under my mentor Richard Lord PhD, who taught me that as scientists and clinicians we have no choice but to embrace uncertainty. No laboratory tests are as precise as many of us would like to think they are - microbiome, organic acid, nutrient testing, those foundational tools of functional medicine that we are very comfortable using, included. This applies to standard labs too - I recently received a notification from one of the two biggest labs in the US stating that, due to a change in the testing instrument used, values for red cell indices (the oldest tests on the planet!) would be altered compared to prior results. As clinicians we have to grapple with uncomfortable uncertainty in medicine every single day - from that reality we still have to move forward and make the best clinical decisions we can. Epigenetic age testing is simply another tool in the mix that can add value to understanding a patient's picture, and we can use it even as we interpret it with a similar acknowledgement of uncertainty. If you would like to add your thoughts to this discussion, please share below. - DrKF

Check out the show notes at https://www.drkarafitzgerald.com/fxme... for the full list of links and resources.

GUEST DETAILS
Matt Kaeberlein PhD, CEO, Optispan https://tinyurl.com/2r89rvdd

Dr. Matt Kaeberlein is the Chief Executive Officer at Optispan, Affiliate Professor of Oral Health Sciences at the University of Washington, and Co-Founder of the Dog Aging Project and Dog Aging Institute. Dr. Kaeberlein’s research seeks to define biological mechanisms of aging to facilitate translational approaches that promote healthspan and improve quality of life for people and companion animals.

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SHOW NOTES
Dr. Matt Kaeberlein https://www.optispan.life/company

Dog Aging Project https://tinyurl.com/5d5krpaw

Dog Aging Institute https://tinyurl.com/62enuwzc

Biomarkers of Aging Consortium https://tinyurl.com/2hzc52bs

The retardation of aging by caloric restriction: its significance in the transgenic era https://tinyurl.com/mwdchy4h

Antiaging diets: Separating fact from fiction https://tinyurl.com/ywfkra85

Evaluation of off-label rapamycin use to promote healthspan in 333 adults https://tinyurl.com/ytebk5un

The million-molecule challenge: a moonshot project to rapidly advance longevity intervention discovery https://tinyurl.com/s6nm48dp

ExplaiNAble BioLogical Age (ENABL Age)... https://tinyurl.com/5mb6hf79

PEARL trial https://tinyurl.com/363yy4m6

2 years of calorie restriction and cardiometabolic risk (CALERIE) trial https://tinyurl.com/38cyr526

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