Скачать или смотреть Dirithromycin; Chemical name, Molecular Formula, Molar mass, Chemical Structure

Dirithromycin is a macrolide antibiotic, specifically a prodrug of erythromycyclamine (a derivative of erythromycin). It was developed to improve oral bioavailability and stability compared to erythromycin, though it is less commonly used today.

🔬 Dirithromycin Key Chemical Information
Chemical name (IUPAC):
(3R,4S,5S,6R,7R,9R,10R,11R,12R,13S,14R)-6-[(2R,3R,4R,5R,6R)-4-(dimethylamino)-3-hydroxy-6-methyloxan-2-yl]oxy-14-ethyl-12,13-dihydroxy-4-(methoxycarbonyl)-10-methoxy-3,5,7,9,11,13-hexamethyl-1-oxacyclotetradecane-2,8-dione

Molecular formula:
C₄₂H₇₈N₂O₁₄

Molar mass:
822.1 g/mol

Chemical structure:

Built on a 14-membered macrolide lactone ring.

Contains multiple hydroxyl (-OH) and methoxy (-OCH₃) groups.

Linked to sugar moieties (desosamine-like amino sugar).

Dirithromycin itself is a prodrug, converted in the body to the active compound erythromycyclamine.

⚡ Pharmacological Notes
Drug class: Macrolide antibiotic.

Mechanism of action: Binds to the 50S ribosomal subunit, inhibiting bacterial protein synthesis.

Clinical use: Respiratory tract infections, skin infections.

Special feature: As a prodrug, it is more stable in gastric acid and has better absorption than erythromycin.

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