Скачать или смотреть Lecture 4. Nanotoxicity on cellular level

In this lecture, we will discuss in detail, how nanoparticles can cause cell damage. We will start with cell entry pathways, such as phagocytosis or pinocytosis. Further, I will give some mechanisms related to the generation of ROS, and how they can damage cells. Special attention will be paid to Fenton's reaction, which involved in ferroptosis. Also, some nanoparticle's behavior can be altered, when they are introduced in different media. We will also discuss genotoxicity and possible ways to damage DNA, and how they can affect cell viability. The shape-dependent effect of nanoparticles is also important. We will discuss how nanoparticles with different sharpness can affect their accumulation inside the cells. Some brief information will be provided on damage to the cytoskeleton, induction of autophagy, and damage to mitochondria.