Scientist Stories: Jolanda Van Leeuwen, Analysis of genetic interactions from yeast to human

The main research mission of the Van Leeuwen lab is to use functional genomics tools to improve our understanding of how mutations can interact to produce unexpected phenotypes, and how this determines the severity of genetic traits. Our research specifically focusses on suppression interactions, in which the accumulation of secondary mutations elsewhere in the genome can compensate for the deleterious effects of the primary mutation. For human disease genes, suppressors can represent strong targets for therapeutic intervention.

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