In this presentation, Dr. Theoharis Theoharides, a Professor, Vice Chair of Clinical Immunology, and Director at the Institute for Neuro-Immune Medicine (Clearwater), dives deep into the pathophysiology of mast cells beyond their well-known role in allergic responses.
Dr. Theoharides provides a historical overview of mast cell research, explains where and how mast cells function in the body, and outlines the three main categories of mast cell disorders, including their corresponding diagnostic codes. He also explores the role of histamine, common triggers of mast cell activation, and the wide range of conditions now associated with mast cell dysfunction.
Additionally, Dr. Theoharides highlights key physical and clinical signs that may suggest mast cell activation, offers insights on helpful diagnostic tests, and shares practical approaches for managing symptoms at home, including medications and supplements that may provide relief.
Key points:
00:01 Introduction
01:24 Mast cells in the human body
03:29 Mast cells and stress
04:27 Immunoglobulin E (IgE) as a mast cell receptor
05:48 MRGPRX2 in non-IgE-mediated mast cell activation
06:44 High-affinity receptors for molecules
09:07 Mast cells do not live in isolation
10:17 3 categories of mast cell disorders
11:30 Diagnostic codes for mast cell disorders
12:28 Atopic and non-atopic disorders
13:31 Foods that release histamine
14:27 Important enzymes to measure
15:18 Mast cells affect every tissue in the body
16:30 Signs of mast cell activation
19:47 Mast cell activation syndrome
21:19 Association of mast cell activation to the “triad”
22:22 Hyper tryptasemia and mast cell activation
23:56 High tryptase levels and kidney disease
25:50 Practical signs for mast cell activation
26:34 Diagnostic tests to determine mast cell activation
30:38 Molecules associated with mast cells
32:14 The Basophil Activation Test
34:05 Other helpful diagnostic tests
36:31 Mast cells can damage any tissue
37:24 Addressing mast cell activation
38:25 Recommended antihistamines and their effects
41:05 DAO supplements don’t work
42:52 Chromaline is not good for humans
44:25 Flavonoids for mast cell activation
48:26 Why choose pure products and other helpful supplements
50:25 Antihistamine dosage and its effects
51:46 Addressing food intolerance and physical conditions
52:49 Addressing systemic mastocytosis
53:18 Other drugs patients may use
54:11 Mast cells' involvement in inflammation and fibromyalgia
Dr. Theoharis Theoharides is a Professor, Vice Chair of Clinical Immunology, and Director at the Institute for Neuro-Immune Medicine-Clearwater, an Adjunct Professor of Immunology at Tufts School of Medicine, where he was a Professor of Pharmacology and Internal Medicine, and also the Director of Molecular Immunopharmacology & Drug Discovery, and Clinical Pharmacologist at the Massachusetts Drug Formulary Commission (1983-2022). He received his BA, MS, MPhil, PhD, and MD degrees and the Winternitz Price in Pathology from Yale University and received a Certificate in Global Leadership from Tufts Fletcher School of Law and Diplomacy and a Fellowship at Harvard Kennedy School of Government. He trained in internal medicine at New England Medical Center, which awarded him the Oliver Smith Award, “recognizing excellence, compassion, and service.” Dr. Theoharides has 485 publications (46,491 citations; h-index 106), placing him in the world’s top 2% of most cited authors, and he was rated the worldwide expert on mast cells by Expertscape. He was inducted into the Alpha Omega Alpha National Medical Honor Society, the Rare Diseases Hall of Fame, and the World Academy of Sciences.
Website: https://www.drtheoharides.com
LinkedIn: linkedin.com/in/theoharis-theoharides-ms-phd-md-faaaai-67123735
Instagram: / dr.theoharides
Learn more about the Institute for Neuro-Immune Medicine here.
Website: https://www.nova.edu/nim/
Facebook: / instituteforneuroimmunemedicine
Instagram: / nsu_inim
Twitter: / nsu_inim
#Allergies #MastCellActivation #MastCellDisorders
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