Скачать или смотреть Self-Organization, Flows, and Transport in (and of) Living Cells

Delivered by Michael Shelley, the director of the Center for Computational Biology at the Flatiron Institute and Lyttle Professor of Applied Mathematics at the Courant Institute of New York University, the 2025 Stephen H. Davis Lecture explored how organisms organize their internal contents at the microscale through dynamic processes. Examples included the positioning of pronuclei in early C. elegans embryos via the interaction of centrosomal arrays and molecular motors, self-organized intracellular flows in female Drosophila that transport materials across growing egg cells to establish functional asymmetries, and the packing and storage of ultralong sperm in males in highly ordered states. The work presented combined multiscale modeling and simulation with quantitative experiments, using theoretical frameworks from fluid and nonlinear dynamics, coarse-graining, and active matter to reveal the biophysical mechanisms that allow living systems to build, move, and self-organize.