Скачать или смотреть 2025 Nobel Prize in Physiology or Medicine: A Cure for Autoimmune Disease?

The Nobel Prize in Physiology or Medicine 2025 has been awarded for a discovery that could finally unlock a cure for autoimmune disease. For decades, we've wondered how our immune system knows not to attack itself—and what happens when that control system fails. This groundbreaking Nobel Prize research reveals the immune system's master "off" switch: a single gene called Foxp3. Join us as we unpack the incredible story of how the discoveries that earned this year's Nobel Prize identified the "peacekeeper" T-cells that prevent fatal autoimmunity. We'll explore how this Nobel Prize breakthrough not only rewrites our understanding of immunology but also paves the way for revolutionary gene therapies. The potential unlocked by this incredible Nobel Prize discovery could allow us to reprogram our own cells, potentially leading to a permanent cure for autoimmune diseases.

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00:00 The 2025 Nobel Prize in Medicine
01:40 1995: Shimon Sakaguchi's Breakthrough
03:52 2001: The Scurfy Mouse & A Fatal Disorder
04:51 The Discovery of the Foxp3 Gene
06:01 The Human Connection: IPEX Syndrome
07:35 2003: The Grand Synthesis
09:19 Reprogramming T-Cells with Foxp3
11:33 The Stunning CTLA-4 Rescue Experiment
13:30 Therapeutic Potential: Curing Autoimmune Disease
15:13 The Future of Medicine

🎬 Don’t forget to turn on CC subtitles!

Abbreviations:
CD: Cluster of Differentiation
CTLA-4: Cytolytic T-lymphocyte-associated antigen 4
Foxp3/FOXP3: Forkhead box P3
IBD: Inflammatory Bowel Disease
IL-10: Interleukin-10
IPEX: Immune dysregulation, Polyendocrinopathy, Enteropathy, X-linked Syndrome
mRNA: messenger Ribonucleic acid
RNA: Ribonucleic acid
T_R cell: Regulatory T-cell
TGF-β: Transforming growth factor-beta

References:
1. Wildin RS, Ramsdell F, Peake J, Faravelli F, Casanova JL, Buist N, et al. The immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome (IPEX) is caused by mutations of FOXP3. Nat Genet. 2001;27(1):20-1.
2. Brunkow ME, Jeffery EW, Hjerrild KA, Paeper B, Clark LB, Yasayko SA, et al. Disruption of a new forkhead/winged-helix protein, scurfin, results in the fatal lymphoproliferative disorder of the scurfy mouse. Nat Genet. 2001;27(1):68-73.
3. Hori S, Nomura T, Sakaguchi S. Control of regulatory T cell development by the transcription factor Foxp3. Science. 2003;299(5609):1057-61.
4. Khattri R, Cox T, Yasayko SA, Ramsdell F. An essential role for Scurfin in CD4+CD25+ T regulatory cells. Nat Immunol. 2003;4(4):337-42.

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